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Side-by-side financial comparison of Orchestra BioMed Holdings, Inc. (OBIO) and Penumbra Inc (PEN). Click either name above to swap in a different company.
Penumbra Inc is the larger business by last-quarter revenue ($385.4M vs $30.9M, roughly 12.5× Orchestra BioMed Holdings, Inc.). Orchestra BioMed Holdings, Inc. runs the higher net margin — 20.2% vs 12.3%, a 7.9% gap on every dollar of revenue. On growth, Orchestra BioMed Holdings, Inc. posted the faster year-over-year revenue change (12120.2% vs 22.1%). Penumbra Inc produced more free cash flow last quarter ($68.0M vs $-2.3M). Over the past eight quarters, Orchestra BioMed Holdings, Inc.'s revenue compounded faster (606.2% CAGR vs 17.6%).
Orchestra BioMed Holdings, Inc. is a clinical-stage medical technology company focused on developing novel, evidence-based therapeutic solutions for cardiovascular and other high-burden chronic diseases. It collaborates with leading healthcare stakeholders, operates primarily across North American and European markets, with core segments covering interventional cardiology and chronic disease care optimization.
Penumbra, Inc. is an American medical device company headquartered in Alameda, California. The company was founded by Arani Bose and Adam Elsesser in 2004. It manufactures devices for interventional therapies to treat vascular conditions such as stroke and aneurysm.
OBIO vs PEN — Head-to-Head
Income Statement — Q4 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $30.9M | $385.4M |
| Net Profit | $6.2M | $47.3M |
| Gross Margin | 99.8% | 68.0% |
| Operating Margin | 21.8% | 15.4% |
| Net Margin | 20.2% | 12.3% |
| Revenue YoY | 12120.2% | 22.1% |
| Net Profit YoY | 138.7% | 40.6% |
| EPS (diluted) | $0.28 | $1.20 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $30.9M | $385.4M | ||
| Q3 25 | $861.0K | $354.7M | ||
| Q2 25 | $836.0K | $339.5M | ||
| Q1 25 | $868.0K | $324.1M | ||
| Q4 24 | $253.0K | $315.5M | ||
| Q3 24 | $987.0K | $301.0M | ||
| Q2 24 | $778.0K | $299.4M | ||
| Q1 24 | $620.0K | $278.7M |
| Q4 25 | $6.2M | $47.3M | ||
| Q3 25 | $-20.8M | $45.9M | ||
| Q2 25 | $-19.4M | $45.3M | ||
| Q1 25 | $-18.8M | $39.2M | ||
| Q4 24 | $-16.2M | $33.7M | ||
| Q3 24 | $-15.4M | $29.5M | ||
| Q2 24 | $-16.0M | $-60.2M | ||
| Q1 24 | $-13.5M | $11.0M |
| Q4 25 | 99.8% | 68.0% | ||
| Q3 25 | 94.3% | 67.8% | ||
| Q2 25 | 94.5% | 66.0% | ||
| Q1 25 | 94.9% | 66.6% | ||
| Q4 24 | 77.1% | 66.8% | ||
| Q3 24 | 93.1% | 66.5% | ||
| Q2 24 | 94.3% | 54.4% | ||
| Q1 24 | 94.5% | 65.0% |
| Q4 25 | 21.8% | 15.4% | ||
| Q3 25 | -2359.2% | 13.8% | ||
| Q2 25 | -2311.8% | 12.0% | ||
| Q1 25 | -2179.8% | 12.4% | ||
| Q4 24 | -6591.7% | 13.6% | ||
| Q3 24 | -1655.7% | 11.7% | ||
| Q2 24 | -2167.0% | -27.0% | ||
| Q1 24 | -2326.3% | 4.3% |
| Q4 25 | 20.2% | 12.3% | ||
| Q3 25 | -2419.0% | 12.9% | ||
| Q2 25 | -2316.1% | 13.3% | ||
| Q1 25 | -2160.7% | 12.1% | ||
| Q4 24 | -6385.4% | 10.7% | ||
| Q3 24 | -1562.9% | 9.8% | ||
| Q2 24 | -2054.0% | -20.1% | ||
| Q1 24 | -2171.5% | 3.9% |
| Q4 25 | $0.28 | $1.20 | ||
| Q3 25 | $-0.40 | $1.17 | ||
| Q2 25 | $-0.50 | $1.15 | ||
| Q1 25 | $-0.49 | $1.00 | ||
| Q4 24 | $-0.42 | $0.88 | ||
| Q3 24 | $-0.41 | $0.75 | ||
| Q2 24 | $-0.45 | $-1.55 | ||
| Q1 24 | $-0.38 | $0.28 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $106.5M | $186.9M |
| Total DebtLower is stronger | $15.0M | — |
| Stockholders' EquityBook value | $53.6M | $1.4B |
| Total Assets | $114.9M | $1.8B |
| Debt / EquityLower = less leverage | 0.28× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $106.5M | $186.9M | ||
| Q3 25 | $95.8M | $321.0M | ||
| Q2 25 | $33.9M | $421.8M | ||
| Q1 25 | $49.9M | $376.1M | ||
| Q4 24 | $66.8M | $324.4M | ||
| Q3 24 | $66.9M | $280.5M | ||
| Q2 24 | $65.2M | $288.3M | ||
| Q1 24 | $75.0M | $223.1M |
| Q4 25 | $15.0M | — | ||
| Q3 25 | $15.0M | — | ||
| Q2 25 | $15.0M | — | ||
| Q1 25 | $15.0M | — | ||
| Q4 24 | $15.0M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $53.6M | $1.4B | ||
| Q3 25 | $43.7M | $1.4B | ||
| Q2 25 | $295.0K | $1.3B | ||
| Q1 25 | $16.9M | $1.2B | ||
| Q4 24 | $33.0M | $1.2B | ||
| Q3 24 | $46.2M | $1.1B | ||
| Q2 24 | $44.1M | $1.2B | ||
| Q1 24 | $57.2M | $1.2B |
| Q4 25 | $114.9M | $1.8B | ||
| Q3 25 | $104.8M | $1.7B | ||
| Q2 25 | $42.8M | $1.7B | ||
| Q1 25 | $59.1M | $1.6B | ||
| Q4 24 | $76.2M | $1.5B | ||
| Q3 24 | $75.3M | $1.5B | ||
| Q2 24 | $72.4M | $1.5B | ||
| Q1 24 | $82.6M | $1.6B |
| Q4 25 | 0.28× | — | ||
| Q3 25 | 0.34× | — | ||
| Q2 25 | 50.85× | — | ||
| Q1 25 | 0.89× | — | ||
| Q4 24 | 0.46× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-2.3M | $86.5M |
| Free Cash FlowOCF − Capex | $-2.3M | $68.0M |
| FCF MarginFCF / Revenue | -7.4% | 17.7% |
| Capex IntensityCapex / Revenue | 0.1% | 4.8% |
| Cash ConversionOCF / Net Profit | -0.36× | 1.83× |
| TTM Free Cash FlowTrailing 4 quarters | $-49.5M | $174.9M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-2.3M | $86.5M | ||
| Q3 25 | $-14.6M | $58.3M | ||
| Q2 25 | $-15.5M | $44.9M | ||
| Q1 25 | $-16.6M | $49.0M | ||
| Q4 24 | $-13.5M | $51.1M | ||
| Q3 24 | $-13.7M | $56.5M | ||
| Q2 24 | $-10.2M | $22.6M | ||
| Q1 24 | $-13.1M | $38.3M |
| Q4 25 | $-2.3M | $68.0M | ||
| Q3 25 | $-14.9M | $42.0M | ||
| Q2 25 | $-15.6M | $29.4M | ||
| Q1 25 | $-16.7M | $35.5M | ||
| Q4 24 | $-13.6M | $45.7M | ||
| Q3 24 | $-13.8M | $51.0M | ||
| Q2 24 | $-10.3M | $18.1M | ||
| Q1 24 | $-13.1M | $32.5M |
| Q4 25 | -7.4% | 17.7% | ||
| Q3 25 | -1725.9% | 11.8% | ||
| Q2 25 | -1861.4% | 8.7% | ||
| Q1 25 | -1927.2% | 11.0% | ||
| Q4 24 | -5392.9% | 14.5% | ||
| Q3 24 | -1394.9% | 16.9% | ||
| Q2 24 | -1325.6% | 6.0% | ||
| Q1 24 | -2116.5% | 11.7% |
| Q4 25 | 0.1% | 4.8% | ||
| Q3 25 | 36.0% | 4.6% | ||
| Q2 25 | 4.1% | 4.6% | ||
| Q1 25 | 12.9% | 4.2% | ||
| Q4 24 | 41.9% | 1.7% | ||
| Q3 24 | 6.9% | 1.8% | ||
| Q2 24 | 13.8% | 1.5% | ||
| Q1 24 | 1.3% | 2.1% |
| Q4 25 | -0.36× | 1.83× | ||
| Q3 25 | — | 1.27× | ||
| Q2 25 | — | 0.99× | ||
| Q1 25 | — | 1.25× | ||
| Q4 24 | — | 1.52× | ||
| Q3 24 | — | 1.91× | ||
| Q2 24 | — | — | ||
| Q1 24 | — | 3.48× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
