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Side-by-side financial comparison of Prime Medicine, Inc. (PRME) and PALVELLA THERAPEUTICS, INC. (PVLA). Click either name above to swap in a different company.
Prime Medicine, Inc. is the larger business by last-quarter revenue ($838.0K vs $520.0K, roughly 1.6× PALVELLA THERAPEUTICS, INC.). On growth, PALVELLA THERAPEUTICS, INC. posted the faster year-over-year revenue change (14.3% vs -61.6%).
Prime Medicine, Inc. is an American biotechnology company developing gene therapies based on prime editing. The company is headquartered in Cambridge, Massachusetts.
Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing targeted therapies for rare, debilitating genetic diseases with high unmet medical needs. Its lead product candidates address congenital disorders, serving global patient populations that lack effective existing treatment options.
PRME vs PVLA — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $838.0K | $520.0K |
| Net Profit | $-46.1M | — |
| Gross Margin | — | — |
| Operating Margin | -5800.5% | — |
| Net Margin | -5498.7% | — |
| Revenue YoY | -61.6% | 14.3% |
| Net Profit YoY | -9.0% | -221.8% |
| EPS (diluted) | $-0.22 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $838.0K | $520.0K | ||
| Q3 25 | $1.2M | $628.0K | ||
| Q2 25 | $1.1M | $690.0K | ||
| Q1 25 | $1.5M | $752.0K | ||
| Q4 24 | $2.2M | — | ||
| Q3 24 | — | $0 | ||
| Q2 24 | $0 | $0 | ||
| Q1 24 | $591.0K | $53.0K |
| Q4 25 | $-46.1M | — | ||
| Q3 25 | $-50.6M | $-11.3M | ||
| Q2 25 | $-52.6M | $-9.5M | ||
| Q1 25 | $-51.9M | $-8.2M | ||
| Q4 24 | $-42.3M | — | ||
| Q3 24 | — | $-6.8M | ||
| Q2 24 | $-55.3M | $-4.2M | ||
| Q1 24 | $-45.8M | $-2.5M |
| Q4 25 | -5800.5% | — | ||
| Q3 25 | -4406.0% | -1620.5% | ||
| Q2 25 | -4787.2% | -1340.6% | ||
| Q1 25 | -3603.3% | -1046.7% | ||
| Q4 24 | -2025.7% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -8179.5% | -3318.9% |
| Q4 25 | -5498.7% | — | ||
| Q3 25 | -4129.1% | -1806.5% | ||
| Q2 25 | -4716.7% | -1372.6% | ||
| Q1 25 | -3568.8% | -1088.4% | ||
| Q4 24 | -1936.6% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -7743.0% | -4784.9% |
| Q4 25 | $-0.22 | — | ||
| Q3 25 | $-0.32 | $-1.03 | ||
| Q2 25 | $-0.41 | $-0.86 | ||
| Q1 25 | $-0.40 | $-0.74 | ||
| Q4 24 | $-0.31 | — | ||
| Q3 24 | — | $-3.94 | ||
| Q2 24 | $-0.46 | $-2.47 | ||
| Q1 24 | $-0.44 | $-1.54 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $63.0M | $58.0M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $120.9M | $28.0M |
| Total Assets | $342.7M | $59.6M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $63.0M | $58.0M | ||
| Q3 25 | $71.4M | $63.6M | ||
| Q2 25 | $53.8M | $70.4M | ||
| Q1 25 | $91.9M | $75.6M | ||
| Q4 24 | $182.5M | — | ||
| Q3 24 | — | $19.4M | ||
| Q2 24 | $55.6M | $19.7M | ||
| Q1 24 | $94.2M | $19.1M |
| Q4 25 | $120.9M | $28.0M | ||
| Q3 25 | $161.8M | $38.7M | ||
| Q2 25 | $60.9M | $47.8M | ||
| Q1 25 | $106.9M | $55.6M | ||
| Q4 24 | $153.1M | — | ||
| Q3 24 | — | $-87.4M | ||
| Q2 24 | $196.6M | $-80.8M | ||
| Q1 24 | $243.8M | $-76.9M |
| Q4 25 | $342.7M | $59.6M | ||
| Q3 25 | $385.0M | $66.9M | ||
| Q2 25 | $279.0M | $73.7M | ||
| Q1 25 | $328.2M | $79.4M | ||
| Q4 24 | $297.5M | — | ||
| Q3 24 | — | $20.5M | ||
| Q2 24 | $259.7M | $25.1M | ||
| Q1 24 | $311.4M | $29.5M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-37.3M | $-25.0M |
| Free Cash FlowOCF − Capex | $-37.5M | — |
| FCF MarginFCF / Revenue | -4480.4% | — |
| Capex IntensityCapex / Revenue | 34.6% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-167.1M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-37.3M | $-25.0M | ||
| Q3 25 | $-35.0M | $-7.9M | ||
| Q2 25 | $-41.4M | $-5.4M | ||
| Q1 25 | $-48.9M | $-6.8M | ||
| Q4 24 | $16.2M | — | ||
| Q3 24 | — | $-2.7M | ||
| Q2 24 | $-45.5M | $-1.6M | ||
| Q1 24 | $-67.7M | $-1.1M |
| Q4 25 | $-37.5M | — | ||
| Q3 25 | $-35.3M | — | ||
| Q2 25 | $-43.0M | — | ||
| Q1 25 | $-51.3M | — | ||
| Q4 24 | $14.5M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | $-47.4M | — | ||
| Q1 24 | $-70.0M | — |
| Q4 25 | -4480.4% | — | ||
| Q3 25 | -2880.5% | — | ||
| Q2 25 | -3855.1% | — | ||
| Q1 25 | -3526.8% | — | ||
| Q4 24 | 662.1% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -11849.6% | — |
| Q4 25 | 34.6% | — | ||
| Q3 25 | 20.2% | — | ||
| Q2 25 | 141.0% | — | ||
| Q1 25 | 166.6% | — | ||
| Q4 24 | 82.0% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | 393.2% | 0.0% |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
