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Side-by-side financial comparison of PROTHENA CORP PUBLIC LTD CO (PRTA) and Shuttle Pharmaceuticals Holdings, Inc. (SHPH). Click either name above to swap in a different company.
Shuttle Pharmaceuticals Holdings, Inc. is the larger business by last-quarter revenue ($22.0K vs $21.0K, roughly 1.0× PROTHENA CORP PUBLIC LTD CO). On growth, Shuttle Pharmaceuticals Holdings, Inc. posted the faster year-over-year revenue change (14.0% vs -99.0%).
Prothena Corporation plc is a late-stage clinical biotechnology firm focused on developing and commercializing innovative antibody therapies for neurodegenerative disorders, rare diseases and immune-related conditions. Its core pipeline targets unmet medical needs including amyloidosis, Parkinson's and Alzheimer's, serving key markets across North America, Europe and the Asia-Pacific.
Shuttle Pharmaceuticals Holdings, Inc. is a US-based clinical-stage biopharmaceutical company focused on developing novel radioprotective therapies and cancer supportive care products. It primarily operates in the oncology care segment, targeting unmet medical needs to reduce side effects of radiation therapy for cancer patients, and collaborates with clinical research partners to advance its late-stage product pipeline.
PRTA vs SHPH — Head-to-Head
Income Statement — Q4 FY2025 vs Q2 FY2024
| Metric | | |
|---|---|---|
| Revenue | $21.0K | $22.0K |
| Net Profit | — | $-2.0M |
| Gross Margin | — | — |
| Operating Margin | — | -6751.5% |
| Net Margin | — | -9249.6% |
| Revenue YoY | -99.0% | 14.0% |
| Net Profit YoY | 62.7% | 7.0% |
| EPS (diluted) | — | $-24.12 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $21.0K | — | ||
| Q3 25 | $2.4M | — | ||
| Q2 25 | $4.4M | — | ||
| Q1 25 | $2.8M | — | ||
| Q4 24 | $2.1M | — | ||
| Q3 24 | $970.0K | — | ||
| Q2 24 | $132.0M | $22.0K | ||
| Q1 24 | $50.0K | $13.7K |
| Q4 25 | — | — | ||
| Q3 25 | $-36.5M | — | ||
| Q2 25 | $-125.8M | — | ||
| Q1 25 | $-60.2M | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $-59.0M | — | ||
| Q2 24 | $66.9M | $-2.0M | ||
| Q1 24 | $-72.2M | $-1.7M |
| Q4 25 | — | — | ||
| Q3 25 | -1666.3% | — | ||
| Q2 25 | -1914.4% | — | ||
| Q1 25 | -2319.0% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | -6857.0% | — | ||
| Q2 24 | 44.2% | -6751.5% | ||
| Q1 24 | -163056.0% | -10144.7% |
| Q4 25 | — | — | ||
| Q3 25 | -1513.1% | — | ||
| Q2 25 | -2845.4% | — | ||
| Q1 25 | -2128.5% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | -6082.6% | — | ||
| Q2 24 | 50.7% | -9249.6% | ||
| Q1 24 | -144478.0% | -12680.6% |
| Q4 25 | — | — | ||
| Q3 25 | $-0.68 | — | ||
| Q2 25 | $-2.34 | — | ||
| Q1 25 | $-1.12 | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $-1.10 | — | ||
| Q2 24 | $1.22 | $-24.12 | ||
| Q1 24 | $-1.34 | $-0.83 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $307.5M | $2.3M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $280.5M | $801.4K |
| Total Assets | $326.8M | $2.8M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $307.5M | — | ||
| Q3 25 | $330.8M | — | ||
| Q2 25 | $371.4M | — | ||
| Q1 25 | $417.9M | — | ||
| Q4 24 | $471.4M | — | ||
| Q3 24 | $519.3M | — | ||
| Q2 24 | $564.1M | $2.3M | ||
| Q1 24 | $546.5M | $4.2M |
| Q4 25 | $280.5M | — | ||
| Q3 25 | $295.0M | — | ||
| Q2 25 | $324.3M | — | ||
| Q1 25 | $437.7M | — | ||
| Q4 24 | $486.9M | — | ||
| Q3 24 | $534.4M | — | ||
| Q2 24 | $581.9M | $801.4K | ||
| Q1 24 | $502.4M | $2.8M |
| Q4 25 | $326.8M | — | ||
| Q3 25 | $352.6M | — | ||
| Q2 25 | $399.1M | — | ||
| Q1 25 | $495.3M | — | ||
| Q4 24 | $547.1M | — | ||
| Q3 24 | $595.3M | — | ||
| Q2 24 | $645.6M | $2.8M | ||
| Q1 24 | $623.2M | $4.8M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-163.6M | $-1.4M |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | — | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-163.6M | — | ||
| Q3 25 | $-40.6M | — | ||
| Q2 25 | $-46.3M | — | ||
| Q1 25 | $-53.4M | — | ||
| Q4 24 | $-150.1M | — | ||
| Q3 24 | $-45.2M | — | ||
| Q2 24 | $16.0M | $-1.4M | ||
| Q1 24 | $-73.1M | $-1.2M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | 0.24× | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
