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Side-by-side financial comparison of Chicago Atlantic Real Estate Finance, Inc. (REFI) and Spero Therapeutics, Inc. (SPRO). Click either name above to swap in a different company.

Chicago Atlantic Real Estate Finance, Inc. is the larger business by last-quarter revenue ($14.2M vs $12.6M, roughly 1.1× Spero Therapeutics, Inc.). Spero Therapeutics, Inc. runs the higher net margin — 250.7% vs 57.3%, a 193.4% gap on every dollar of revenue. On growth, Spero Therapeutics, Inc. posted the faster year-over-year revenue change (24080.8% vs 1.2%). Over the past eight quarters, Spero Therapeutics, Inc.'s revenue compounded faster (847.7% CAGR vs 3.7%).

Chicago Atlantic Real Estate Finance, Inc. is a commercial real estate finance firm that primarily originates, underwrites, and manages secured senior mortgage loans for US commercial real estate assets. Its core segments include multifamily residential, industrial, retail, and office properties, serving experienced real estate operators and project sponsors.

REFI vs SPRO — Head-to-Head

Bigger by revenue
REFI
REFI
1.1× larger
REFI
$14.2M
$12.6M
SPRO
Growing faster (revenue YoY)
SPRO
SPRO
+24079.6% gap
SPRO
24080.8%
1.2%
REFI
Higher net margin
SPRO
SPRO
193.4% more per $
SPRO
250.7%
57.3%
REFI
Faster 2-yr revenue CAGR
SPRO
SPRO
Annualised
SPRO
847.7%
3.7%
REFI

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
REFI
REFI
SPRO
SPRO
Revenue
$14.2M
$12.6M
Net Profit
$8.2M
$31.5M
Gross Margin
Operating Margin
57.3%
Net Margin
57.3%
250.7%
Revenue YoY
1.2%
24080.8%
Net Profit YoY
3.0%
250.9%
EPS (diluted)
$0.38
$0.56

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
REFI
REFI
SPRO
SPRO
Q4 25
$14.2M
$12.6M
Q3 25
$13.7M
$0
Q2 25
$14.4M
$0
Q1 25
$13.0M
$12.0K
Q4 24
$14.1M
$52.0K
Q3 24
$14.5M
$65.0K
Q2 24
$13.2M
$114.0K
Q1 24
$13.2M
$140.0K
Net Profit
REFI
REFI
SPRO
SPRO
Q4 25
$8.2M
$31.5M
Q3 25
$8.9M
$-7.4M
Q2 25
$8.9M
$-1.7M
Q1 25
$10.0M
$-13.9M
Q4 24
$7.9M
Q3 24
$11.2M
$-17.1M
Q2 24
$9.2M
$-17.9M
Q1 24
$8.7M
$-12.7M
Operating Margin
REFI
REFI
SPRO
SPRO
Q4 25
57.3%
Q3 25
65.3%
Q2 25
61.5%
Q1 25
77.0%
-122758.3%
Q4 24
56.3%
Q3 24
77.5%
-28604.6%
Q2 24
69.7%
-16720.2%
Q1 24
65.9%
-9987.1%
Net Margin
REFI
REFI
SPRO
SPRO
Q4 25
57.3%
250.7%
Q3 25
65.3%
Q2 25
61.5%
Q1 25
77.0%
-115550.0%
Q4 24
56.3%
Q3 24
77.5%
-26380.0%
Q2 24
69.7%
-15668.4%
Q1 24
65.9%
-9049.3%
EPS (diluted)
REFI
REFI
SPRO
SPRO
Q4 25
$0.38
$0.56
Q3 25
$0.42
$-0.13
Q2 25
$0.41
$-0.03
Q1 25
$0.47
$-0.25
Q4 24
$0.39
Q3 24
$0.56
$-0.32
Q2 24
$0.46
$-0.33
Q1 24
$0.47
$-0.24

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
REFI
REFI
SPRO
SPRO
Cash + ST InvestmentsLiquidity on hand
$14.9M
$40.3M
Total DebtLower is stronger
$49.3M
Stockholders' EquityBook value
$307.8M
$59.0M
Total Assets
$424.9M
$68.9M
Debt / EquityLower = less leverage
0.16×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
REFI
REFI
SPRO
SPRO
Q4 25
$14.9M
$40.3M
Q3 25
$28.9M
$48.6M
Q2 25
$35.6M
$31.2M
Q1 25
$9.9M
$48.9M
Q4 24
$26.4M
$52.9M
Q3 24
$6.8M
$76.3M
Q2 24
$7.1M
$63.5M
Q1 24
$6.9M
$82.3M
Total Debt
REFI
REFI
SPRO
SPRO
Q4 25
$49.3M
Q3 25
$49.3M
Q2 25
$49.2M
Q1 25
$49.2M
Q4 24
$49.1M
Q3 24
$54.0M
Q2 24
$76.8M
Q1 24
Stockholders' Equity
REFI
REFI
SPRO
SPRO
Q4 25
$307.8M
$59.0M
Q3 25
$309.9M
$26.5M
Q2 25
$310.0M
$32.8M
Q1 25
$310.8M
$33.8M
Q4 24
$309.0M
$46.1M
Q3 24
$295.5M
$65.5M
Q2 24
$292.7M
$80.5M
Q1 24
$286.0M
$96.2M
Total Assets
REFI
REFI
SPRO
SPRO
Q4 25
$424.9M
$68.9M
Q3 25
$427.1M
$54.2M
Q2 25
$455.2M
$62.1M
Q1 25
$414.7M
$77.7M
Q4 24
$435.1M
$110.5M
Q3 24
$365.9M
$135.2M
Q2 24
$386.5M
$149.9M
Q1 24
$383.7M
$167.7M
Debt / Equity
REFI
REFI
SPRO
SPRO
Q4 25
0.16×
Q3 25
0.16×
Q2 25
0.16×
Q1 25
0.16×
Q4 24
0.16×
Q3 24
0.18×
Q2 24
0.26×
Q1 24

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
REFI
REFI
SPRO
SPRO
Operating Cash FlowLast quarter
$28.8M
$-8.4M
Free Cash FlowOCF − Capex
FCF MarginFCF / Revenue
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
3.53×
-0.26×
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
REFI
REFI
SPRO
SPRO
Q4 25
$28.8M
$-8.4M
Q3 25
$8.2M
$17.4M
Q2 25
$6.5M
$-17.7M
Q1 25
$7.6M
$-4.0M
Q4 24
$23.2M
$-23.4M
Q3 24
$8.2M
$12.8M
Q2 24
$6.2M
$-18.7M
Q1 24
$6.9M
$5.9M
Cash Conversion
REFI
REFI
SPRO
SPRO
Q4 25
3.53×
-0.26×
Q3 25
0.92×
Q2 25
0.73×
Q1 25
0.76×
Q4 24
2.92×
Q3 24
0.73×
Q2 24
0.68×
Q1 24
0.79×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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