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Side-by-side financial comparison of Avidity Biosciences, Inc. (RNA) and Xilio Therapeutics, Inc. (XLO). Click either name above to swap in a different company.
Xilio Therapeutics, Inc. is the larger business by last-quarter revenue ($13.7M vs $12.5M, roughly 1.1× Avidity Biosciences, Inc.). Xilio Therapeutics, Inc. runs the higher net margin — 75.7% vs -1398.3%, a 1474.0% gap on every dollar of revenue. Xilio Therapeutics, Inc. produced more free cash flow last quarter ($-2.1M vs $-156.9M).
Eli Lilly and Company, doing business as Lilly, is an American multinational pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by Eli Lilly, a pharmaceutical chemist and Union army veteran during the American Civil War for whom the company was later named.
Xilio Therapeutics is a clinical-stage biotechnology company dedicated to developing novel tumor-selective immunotherapies for cancer treatment. Its product pipeline features candidates engineered to trigger anti-tumor immune responses specifically inside tumor microenvironments, reducing systemic toxicities, and it primarily targets oncology patient populations in North America and other global markets.
RNA vs XLO — Head-to-Head
Income Statement — Q3 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $12.5M | $13.7M |
| Net Profit | $-174.4M | $10.4M |
| Gross Margin | — | — |
| Operating Margin | -1513.5% | -86.5% |
| Net Margin | -1398.3% | 75.7% |
| Revenue YoY | 434.0% | — |
| Net Profit YoY | -117.0% | 179.1% |
| EPS (diluted) | $-1.27 | $-3.74 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $13.7M | ||
| Q3 25 | $12.5M | $19.1M | ||
| Q2 25 | $3.8M | $8.1M | ||
| Q1 25 | $1.6M | $2.9M | ||
| Q4 24 | $3.0M | — | ||
| Q3 24 | $2.3M | — | ||
| Q2 24 | $2.0M | — | ||
| Q1 24 | $3.5M | — |
| Q4 25 | — | $10.4M | ||
| Q3 25 | $-174.4M | $-16.3M | ||
| Q2 25 | $-157.3M | $-15.8M | ||
| Q1 25 | $-115.8M | $-13.3M | ||
| Q4 24 | $-102.3M | — | ||
| Q3 24 | $-80.4M | — | ||
| Q2 24 | $-70.8M | — | ||
| Q1 24 | $-68.9M | — |
| Q4 25 | — | -86.5% | ||
| Q3 25 | -1513.5% | -10.1% | ||
| Q2 25 | -4448.7% | -177.7% | ||
| Q1 25 | -8360.9% | -472.7% | ||
| Q4 24 | -4069.6% | — | ||
| Q3 24 | -4200.9% | — | ||
| Q2 24 | -4040.4% | — | ||
| Q1 24 | -2178.6% | — |
| Q4 25 | — | 75.7% | ||
| Q3 25 | -1398.3% | -85.4% | ||
| Q2 25 | -4089.3% | -196.0% | ||
| Q1 25 | -7360.0% | -452.7% | ||
| Q4 24 | -3439.5% | — | ||
| Q3 24 | -3441.7% | — | ||
| Q2 24 | -3461.8% | — | ||
| Q1 24 | -1943.4% | — |
| Q4 25 | — | $-3.74 | ||
| Q3 25 | $-1.27 | $-0.11 | ||
| Q2 25 | $-1.21 | $-0.16 | ||
| Q1 25 | $-0.90 | $-0.18 | ||
| Q4 24 | $-0.80 | — | ||
| Q3 24 | $-0.65 | — | ||
| Q2 24 | $-0.65 | — | ||
| Q1 24 | $-0.79 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $350.2M | $137.5M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.9B | $35.3M |
| Total Assets | $2.1B | $154.7M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $137.5M | ||
| Q3 25 | $350.2M | $103.8M | ||
| Q2 25 | $243.9M | $121.6M | ||
| Q1 25 | $254.2M | $89.1M | ||
| Q4 24 | $219.9M | — | ||
| Q3 24 | $370.2M | — | ||
| Q2 24 | $575.8M | — | ||
| Q1 24 | $471.4M | — |
| Q4 25 | — | $35.3M | ||
| Q3 25 | $1.9B | $-8.1M | ||
| Q2 25 | $1.2B | $7.1M | ||
| Q1 25 | $1.3B | $10.7M | ||
| Q4 24 | $1.4B | — | ||
| Q3 24 | $1.5B | — | ||
| Q2 24 | $1.2B | — | ||
| Q1 24 | $830.9M | — |
| Q4 25 | — | $154.7M | ||
| Q3 25 | $2.1B | $133.7M | ||
| Q2 25 | $1.4B | $133.8M | ||
| Q1 25 | $1.5B | $103.7M | ||
| Q4 24 | $1.6B | — | ||
| Q3 24 | $1.6B | — | ||
| Q2 24 | $1.3B | — | ||
| Q1 24 | $951.5M | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-156.2M | $-2.0M |
| Free Cash FlowOCF − Capex | $-156.9M | $-2.1M |
| FCF MarginFCF / Revenue | -1257.6% | -15.3% |
| Capex IntensityCapex / Revenue | 5.7% | 0.7% |
| Cash ConversionOCF / Net Profit | — | -0.19× |
| TTM Free Cash FlowTrailing 4 quarters | $-592.3M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $-2.0M | ||
| Q3 25 | $-156.2M | $-17.5M | ||
| Q2 25 | $-199.7M | $-14.5M | ||
| Q1 25 | $-124.8M | $29.0M | ||
| Q4 24 | $-99.9M | — | ||
| Q3 24 | $-65.6M | — | ||
| Q2 24 | $-65.0M | — | ||
| Q1 24 | $-70.4M | — |
| Q4 25 | — | $-2.1M | ||
| Q3 25 | $-156.9M | — | ||
| Q2 25 | $-203.0M | $-14.9M | ||
| Q1 25 | $-128.6M | $29.0M | ||
| Q4 24 | $-103.8M | — | ||
| Q3 24 | $-67.3M | — | ||
| Q2 24 | $-65.5M | — | ||
| Q1 24 | $-71.3M | — |
| Q4 25 | — | -15.3% | ||
| Q3 25 | -1257.6% | — | ||
| Q2 25 | -5277.1% | -184.0% | ||
| Q1 25 | -8174.3% | 988.3% | ||
| Q4 24 | -3491.0% | — | ||
| Q3 24 | -2881.8% | — | ||
| Q2 24 | -3204.6% | — | ||
| Q1 24 | -2012.3% | — |
| Q4 25 | — | 0.7% | ||
| Q3 25 | 5.7% | 0.0% | ||
| Q2 25 | 86.9% | 5.0% | ||
| Q1 25 | 238.6% | 0.8% | ||
| Q4 24 | 131.7% | — | ||
| Q3 24 | 72.9% | — | ||
| Q2 24 | 26.0% | — | ||
| Q1 24 | 25.8% | — |
| Q4 25 | — | -0.19× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
