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Side-by-side financial comparison of ACADIA PHARMACEUTICALS INC (ACAD) and COMMERCE BANCSHARES INC (CBSH). Click either name above to swap in a different company.
COMMERCE BANCSHARES INC is the larger business by last-quarter revenue ($475.7M vs $284.0M, roughly 1.7× ACADIA PHARMACEUTICALS INC). ACADIA PHARMACEUTICALS INC runs the higher net margin — 96.3% vs 29.8%, a 66.6% gap on every dollar of revenue. On growth, COMMERCE BANCSHARES INC posted the faster year-over-year revenue change (11.1% vs 9.4%). Over the past eight quarters, ACADIA PHARMACEUTICALS INC's revenue compounded faster (17.5% CAGR vs 7.1%).
Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Del Mar, San Diego, California.
Commerce Bancshares, Inc. is a regional bank holding company headquartered in Missouri, with principal offices in Kansas City and St. Louis. It is the corporate parent of Commerce Bank, which offers a diversified line of financial services, including business and personal banking, wealth management and investments through its affiliated companies.
ACAD vs CBSH — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $284.0M | $475.7M |
| Net Profit | $273.6M | $141.6M |
| Gross Margin | 90.8% | — |
| Operating Margin | 6.1% | — |
| Net Margin | 96.3% | 29.8% |
| Revenue YoY | 9.4% | 11.1% |
| Net Profit YoY | 90.3% | 10.5% |
| EPS (diluted) | $1.61 | $0.96 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $475.7M | ||
| Q4 25 | $284.0M | $449.4M | ||
| Q3 25 | $278.6M | $441.0M | ||
| Q2 25 | $264.6M | $445.8M | ||
| Q1 25 | $244.3M | $428.1M | ||
| Q4 24 | $259.6M | $422.1M | ||
| Q3 24 | $250.4M | $421.4M | ||
| Q2 24 | $242.0M | $414.5M |
| Q1 26 | — | $141.6M | ||
| Q4 25 | $273.6M | $140.7M | ||
| Q3 25 | $71.8M | $141.5M | ||
| Q2 25 | $26.7M | $152.5M | ||
| Q1 25 | $19.0M | $131.6M | ||
| Q4 24 | $143.7M | $136.1M | ||
| Q3 24 | $32.8M | $138.0M | ||
| Q2 24 | $33.4M | $139.6M |
| Q1 26 | — | — | ||
| Q4 25 | 90.8% | — | ||
| Q3 25 | 92.2% | — | ||
| Q2 25 | 92.2% | — | ||
| Q1 25 | 91.7% | — | ||
| Q4 24 | 91.6% | — | ||
| Q3 24 | 92.5% | — | ||
| Q2 24 | 92.5% | — |
| Q1 26 | — | — | ||
| Q4 25 | 6.1% | 40.8% | ||
| Q3 25 | 12.8% | 41.9% | ||
| Q2 25 | 12.2% | 44.0% | ||
| Q1 25 | 7.9% | 39.2% | ||
| Q4 24 | 59.1% | 41.2% | ||
| Q3 24 | 12.6% | 42.4% | ||
| Q2 24 | 12.6% | 43.4% |
| Q1 26 | — | 29.8% | ||
| Q4 25 | 96.3% | 31.3% | ||
| Q3 25 | 25.8% | 32.1% | ||
| Q2 25 | 10.1% | 34.2% | ||
| Q1 25 | 7.8% | 30.7% | ||
| Q4 24 | 55.4% | 32.2% | ||
| Q3 24 | 13.1% | 32.8% | ||
| Q2 24 | 13.8% | 33.7% |
| Q1 26 | — | $0.96 | ||
| Q4 25 | $1.61 | $0.86 | ||
| Q3 25 | $0.42 | $1.06 | ||
| Q2 25 | $0.16 | $1.14 | ||
| Q1 25 | $0.11 | $0.98 | ||
| Q4 24 | $0.86 | $0.83 | ||
| Q3 24 | $0.20 | $1.01 | ||
| Q2 24 | $0.20 | $1.03 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $177.7M | — |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $4.3B |
| Total Assets | $1.6B | $35.7B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $177.7M | — | ||
| Q3 25 | $258.0M | — | ||
| Q2 25 | $253.6M | — | ||
| Q1 25 | $217.7M | — | ||
| Q4 24 | $319.6M | — | ||
| Q3 24 | $155.1M | — | ||
| Q2 24 | $177.1M | — |
| Q1 26 | — | $4.3B | ||
| Q4 25 | $1.2B | $3.8B | ||
| Q3 25 | $917.3M | $3.8B | ||
| Q2 25 | $822.4M | $3.6B | ||
| Q1 25 | $765.2M | $3.5B | ||
| Q4 24 | $732.8M | $3.3B | ||
| Q3 24 | $577.2M | $3.4B | ||
| Q2 24 | $516.7M | $3.1B |
| Q1 26 | — | $35.7B | ||
| Q4 25 | $1.6B | $32.9B | ||
| Q3 25 | $1.3B | $32.3B | ||
| Q2 25 | $1.2B | $32.3B | ||
| Q1 25 | $1.1B | $32.4B | ||
| Q4 24 | $1.2B | $32.0B | ||
| Q3 24 | $976.9M | $31.5B | ||
| Q2 24 | $914.1M | $30.6B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-48.7M | — |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | — | — |
| Cash ConversionOCF / Net Profit | -0.18× | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $-48.7M | $645.1M | ||
| Q3 25 | $74.3M | $129.0M | ||
| Q2 25 | $64.0M | $111.2M | ||
| Q1 25 | $20.3M | $138.6M | ||
| Q4 24 | $40.4M | $577.9M | ||
| Q3 24 | $63.2M | $431.7M | ||
| Q2 24 | $25.0M | $147.4M |
| Q1 26 | — | — | ||
| Q4 25 | — | $592.4M | ||
| Q3 25 | $73.9M | $113.3M | ||
| Q2 25 | — | $100.5M | ||
| Q1 25 | — | $126.0M | ||
| Q4 24 | — | $531.7M | ||
| Q3 24 | $63.2M | $419.1M | ||
| Q2 24 | — | $138.9M |
| Q1 26 | — | — | ||
| Q4 25 | — | 131.8% | ||
| Q3 25 | 26.5% | 25.7% | ||
| Q2 25 | — | 22.5% | ||
| Q1 25 | — | 29.4% | ||
| Q4 24 | — | 126.0% | ||
| Q3 24 | 25.2% | 99.5% | ||
| Q2 24 | — | 33.5% |
| Q1 26 | — | — | ||
| Q4 25 | — | 11.7% | ||
| Q3 25 | 0.1% | 3.6% | ||
| Q2 25 | — | 2.4% | ||
| Q1 25 | — | 2.9% | ||
| Q4 24 | — | 10.9% | ||
| Q3 24 | 0.0% | 3.0% | ||
| Q2 24 | — | 2.1% |
| Q1 26 | — | — | ||
| Q4 25 | -0.18× | 4.59× | ||
| Q3 25 | 1.03× | 0.91× | ||
| Q2 25 | 2.40× | 0.73× | ||
| Q1 25 | 1.07× | 1.05× | ||
| Q4 24 | 0.28× | 4.25× | ||
| Q3 24 | 1.93× | 3.13× | ||
| Q2 24 | 0.75× | 1.06× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ACAD
| Nuplazid | $174.4M | 61% |
| Daybue | $109.6M | 39% |
CBSH
Segment breakdown not available.
