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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and Dominari Holdings Inc. (DOMH). Click either name above to swap in a different company.
Dominari Holdings Inc. is the larger business by last-quarter revenue ($30.1M vs $20.0M, roughly 1.5× AGIOS PHARMACEUTICALS, INC.). Dominari Holdings Inc. runs the higher net margin — -438.1% vs -541.1%, a 103.0% gap on every dollar of revenue. On growth, Dominari Holdings Inc. posted the faster year-over-year revenue change (220.4% vs 86.1%). Over the past eight quarters, Dominari Holdings Inc.'s revenue compounded faster (369.1% CAGR vs 56.1%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
AGIO vs DOMH — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $30.1M |
| Net Profit | $-108.0M | $-131.8M |
| Gross Margin | 90.6% | — |
| Operating Margin | -608.9% | -8.9% |
| Net Margin | -541.1% | -438.1% |
| Revenue YoY | 86.1% | 220.4% |
| Net Profit YoY | -11.9% | -12426.2% |
| EPS (diluted) | $-1.86 | $-6.94 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $30.1M | ||
| Q3 25 | $12.9M | $50.8M | ||
| Q2 25 | $12.5M | $34.1M | ||
| Q1 25 | $8.7M | $8.1M | ||
| Q4 24 | $10.7M | $9.4M | ||
| Q3 24 | $9.0M | $4.0M | ||
| Q2 24 | $8.6M | $6.2M | ||
| Q1 24 | $8.2M | $1.4M |
| Q4 25 | $-108.0M | $-131.8M | ||
| Q3 25 | $-103.4M | $125.2M | ||
| Q2 25 | $-112.0M | $16.6M | ||
| Q1 25 | $-89.3M | $-32.5M | ||
| Q4 24 | $-96.5M | $1.1M | ||
| Q3 24 | $947.9M | $-4.2M | ||
| Q2 24 | $-96.1M | $-6.1M | ||
| Q1 24 | $-81.5M | $-5.4M |
| Q4 25 | 90.6% | — | ||
| Q3 25 | 87.0% | — | ||
| Q2 25 | 86.3% | — | ||
| Q1 25 | 87.6% | — | ||
| Q4 24 | 88.3% | — | ||
| Q3 24 | 91.3% | — | ||
| Q2 24 | 82.6% | — | ||
| Q1 24 | 92.3% | — |
| Q4 25 | -608.9% | -8.9% | ||
| Q3 25 | -907.4% | -3.1% | ||
| Q2 25 | -1020.1% | -57.0% | ||
| Q1 25 | -1222.0% | -394.6% | ||
| Q4 24 | -1165.3% | 0.4% | ||
| Q3 24 | -1146.9% | -79.1% | ||
| Q2 24 | -1228.3% | -44.3% | ||
| Q1 24 | -1124.3% | -205.2% |
| Q4 25 | -541.1% | -438.1% | ||
| Q3 25 | -803.1% | 246.4% | ||
| Q2 25 | -899.4% | 48.7% | ||
| Q1 25 | -1023.3% | -400.5% | ||
| Q4 24 | -899.6% | 11.4% | ||
| Q3 24 | 10574.7% | -104.2% | ||
| Q2 24 | -1115.7% | -99.1% | ||
| Q1 24 | -995.8% | -398.0% |
| Q4 25 | $-1.86 | $-6.94 | ||
| Q3 25 | $-1.78 | $7.27 | ||
| Q2 25 | $-1.93 | $1.12 | ||
| Q1 25 | $-1.55 | $-3.02 | ||
| Q4 24 | $-1.44 | $0.21 | ||
| Q3 24 | $16.22 | $-0.67 | ||
| Q2 24 | $-1.69 | $-1.01 | ||
| Q1 24 | $-1.45 | $-0.91 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | $80.5M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $69.4M |
| Total Assets | $1.3B | $112.9M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | $80.5M | ||
| Q3 25 | $92.7M | $176.2M | ||
| Q2 25 | $80.9M | $28.2M | ||
| Q1 25 | $79.0M | $18.9M | ||
| Q4 24 | $76.2M | $8.2M | ||
| Q3 24 | $253.7M | $7.2M | ||
| Q2 24 | $84.5M | $12.1M | ||
| Q1 24 | $118.8M | $7.1M |
| Q4 25 | $1.2B | $69.4M | ||
| Q3 25 | $1.3B | $210.2M | ||
| Q2 25 | $1.4B | $88.6M | ||
| Q1 25 | $1.5B | $42.4M | ||
| Q4 24 | $1.5B | $39.9M | ||
| Q3 24 | $1.6B | $38.3M | ||
| Q2 24 | $660.5M | $42.4M | ||
| Q1 24 | $743.9M | $47.7M |
| Q4 25 | $1.3B | $112.9M | ||
| Q3 25 | $1.4B | $223.4M | ||
| Q2 25 | $1.5B | $109.3M | ||
| Q1 25 | $1.6B | $52.3M | ||
| Q4 24 | $1.7B | $47.1M | ||
| Q3 24 | $1.8B | $43.4M | ||
| Q2 24 | $773.1M | $49.1M | ||
| Q1 24 | $849.7M | $52.2M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $22.7M |
| Free Cash FlowOCF − Capex | $-97.3M | — |
| FCF MarginFCF / Revenue | -487.5% | — |
| Capex IntensityCapex / Revenue | 5.6% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $22.7M | ||
| Q3 25 | $-88.2M | $-4.9M | ||
| Q2 25 | $-77.1M | $-353.0K | ||
| Q1 25 | $-111.5M | $1.2M | ||
| Q4 24 | $-133.2M | $-16.7M | ||
| Q3 24 | $-84.2M | $-4.7M | ||
| Q2 24 | $-72.6M | $1.4M | ||
| Q1 24 | $-99.9M | $-8.6M |
| Q4 25 | $-97.3M | — | ||
| Q3 25 | $-89.7M | — | ||
| Q2 25 | $-78.0M | — | ||
| Q1 25 | $-112.3M | — | ||
| Q4 24 | $-134.1M | — | ||
| Q3 24 | $-84.6M | — | ||
| Q2 24 | $-72.7M | — | ||
| Q1 24 | $-100.0M | — |
| Q4 25 | -487.5% | — | ||
| Q3 25 | -696.5% | — | ||
| Q2 25 | -626.2% | — | ||
| Q1 25 | -1286.4% | — | ||
| Q4 24 | -1250.1% | — | ||
| Q3 24 | -944.2% | — | ||
| Q2 24 | -844.4% | — | ||
| Q1 24 | -1221.2% | — |
| Q4 25 | 5.6% | — | ||
| Q3 25 | 12.1% | — | ||
| Q2 25 | 7.0% | — | ||
| Q1 25 | 8.8% | — | ||
| Q4 24 | 9.0% | — | ||
| Q3 24 | 4.7% | — | ||
| Q2 24 | 1.8% | — | ||
| Q1 24 | 1.7% | — |
| Q4 25 | — | — | ||
| Q3 25 | — | -0.04× | ||
| Q2 25 | — | -0.02× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | -15.65× | ||
| Q3 24 | -0.09× | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AGIO
Segment breakdown not available.
DOMH
| Chief Operating Decision Maker | $30.1M | 100% |
| Commissions | $458.0K | 2% |
