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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and TANDY LEATHER FACTORY INC (TLF). Click either name above to swap in a different company.

TANDY LEATHER FACTORY INC is the larger business by last-quarter revenue ($22.3M vs $20.0M, roughly 1.1× AGIOS PHARMACEUTICALS, INC.). TANDY LEATHER FACTORY INC runs the higher net margin — -4.2% vs -541.1%, a 536.9% gap on every dollar of revenue. On growth, AGIOS PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (86.1% vs 8.7%). TANDY LEATHER FACTORY INC produced more free cash flow last quarter ($4.0M vs $-97.3M). Over the past eight quarters, AGIOS PHARMACEUTICALS, INC.'s revenue compounded faster (56.1% CAGR vs 7.4%).

Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.

Tandy Leather Factory, Inc. is an American specialty retailer and wholesale distributor of leather and leatherwork related products. It operates more than 100 stores worldwide. Originally part of the Tandy Corporation, Tandy Leather has gone through a series of acquisitions and mergers, eventually being sold to The Leather Factory in 2000. The Tandy Leather flagship store next to their corporate headquarters in Fort Worth, Texas also houses the Al and Ann Stohlman Leathercraft Museum.

AGIO vs TLF — Head-to-Head

Bigger by revenue
TLF
TLF
1.1× larger
TLF
$22.3M
$20.0M
AGIO
Growing faster (revenue YoY)
AGIO
AGIO
+77.4% gap
AGIO
86.1%
8.7%
TLF
Higher net margin
TLF
TLF
536.9% more per $
TLF
-4.2%
-541.1%
AGIO
More free cash flow
TLF
TLF
$101.4M more FCF
TLF
$4.0M
$-97.3M
AGIO
Faster 2-yr revenue CAGR
AGIO
AGIO
Annualised
AGIO
56.1%
7.4%
TLF

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
AGIO
AGIO
TLF
TLF
Revenue
$20.0M
$22.3M
Net Profit
$-108.0M
$-930.0K
Gross Margin
90.6%
54.3%
Operating Margin
-608.9%
-2.8%
Net Margin
-541.1%
-4.2%
Revenue YoY
86.1%
8.7%
Net Profit YoY
-11.9%
-379.3%
EPS (diluted)
$-1.86
$-0.18

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
AGIO
AGIO
TLF
TLF
Q4 25
$20.0M
$22.3M
Q3 25
$12.9M
$17.3M
Q2 25
$12.5M
$17.8M
Q1 25
$8.7M
$19.0M
Q4 24
$10.7M
$20.5M
Q3 24
$9.0M
$17.4M
Q2 24
$8.6M
$17.3M
Q1 24
$8.2M
$19.3M
Net Profit
AGIO
AGIO
TLF
TLF
Q4 25
$-108.0M
$-930.0K
Q3 25
$-103.4M
$-1.4M
Q2 25
$-112.0M
$-199.0K
Q1 25
$-89.3M
$11.6M
Q4 24
$-96.5M
$333.0K
Q3 24
$947.9M
$-132.0K
Q2 24
$-96.1M
$101.0K
Q1 24
$-81.5M
$525.0K
Gross Margin
AGIO
AGIO
TLF
TLF
Q4 25
90.6%
54.3%
Q3 25
87.0%
58.9%
Q2 25
86.3%
59.5%
Q1 25
87.6%
56.3%
Q4 24
88.3%
53.0%
Q3 24
91.3%
57.8%
Q2 24
82.6%
58.0%
Q1 24
92.3%
56.7%
Operating Margin
AGIO
AGIO
TLF
TLF
Q4 25
-608.9%
-2.8%
Q3 25
-907.4%
-3.9%
Q2 25
-1020.1%
0.4%
Q1 25
-1222.0%
1.4%
Q4 24
-1165.3%
0.9%
Q3 24
-1146.9%
-1.5%
Q2 24
-1228.3%
0.4%
Q1 24
-1124.3%
3.4%
Net Margin
AGIO
AGIO
TLF
TLF
Q4 25
-541.1%
-4.2%
Q3 25
-803.1%
-7.8%
Q2 25
-899.4%
-1.1%
Q1 25
-1023.3%
60.8%
Q4 24
-899.6%
1.6%
Q3 24
10574.7%
-0.8%
Q2 24
-1115.7%
0.6%
Q1 24
-995.8%
2.7%
EPS (diluted)
AGIO
AGIO
TLF
TLF
Q4 25
$-1.86
$-0.18
Q3 25
$-1.78
$-0.17
Q2 25
$-1.93
$-0.02
Q1 25
$-1.55
$1.47
Q4 24
$-1.44
$0.04
Q3 24
$16.22
$-0.02
Q2 24
$-1.69
$0.01
Q1 24
$-1.45
$0.06

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
AGIO
AGIO
TLF
TLF
Cash + ST InvestmentsLiquidity on hand
$89.1M
$16.1M
Total DebtLower is stronger
Stockholders' EquityBook value
$1.2B
$52.6M
Total Assets
$1.3B
$86.6M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
AGIO
AGIO
TLF
TLF
Q4 25
$89.1M
$16.1M
Q3 25
$92.7M
$12.0M
Q2 25
$80.9M
$16.4M
Q1 25
$79.0M
$23.6M
Q4 24
$76.2M
$13.3M
Q3 24
$253.7M
$10.1M
Q2 24
$84.5M
$11.5M
Q1 24
$118.8M
$12.3M
Stockholders' Equity
AGIO
AGIO
TLF
TLF
Q4 25
$1.2B
$52.6M
Q3 25
$1.3B
$53.4M
Q2 25
$1.4B
$56.1M
Q1 25
$1.5B
$55.8M
Q4 24
$1.5B
$57.2M
Q3 24
$1.6B
$57.6M
Q2 24
$660.5M
$57.5M
Q1 24
$743.9M
$57.2M
Total Assets
AGIO
AGIO
TLF
TLF
Q4 25
$1.3B
$86.6M
Q3 25
$1.4B
$84.5M
Q2 25
$1.5B
$76.5M
Q1 25
$1.6B
$77.9M
Q4 24
$1.7B
$74.9M
Q3 24
$1.8B
$73.0M
Q2 24
$773.1M
$72.8M
Q1 24
$849.7M
$72.4M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
AGIO
AGIO
TLF
TLF
Operating Cash FlowLast quarter
$-96.2M
$5.0M
Free Cash FlowOCF − Capex
$-97.3M
$4.0M
FCF MarginFCF / Revenue
-487.5%
18.1%
Capex IntensityCapex / Revenue
5.6%
4.3%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$-377.3M
$-8.1M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
AGIO
AGIO
TLF
TLF
Q4 25
$-96.2M
$5.0M
Q3 25
$-88.2M
$-1.0M
Q2 25
$-77.1M
$-4.0M
Q1 25
$-111.5M
$-536.0K
Q4 24
$-133.2M
$4.5M
Q3 24
$-84.2M
$-535.0K
Q2 24
$-72.6M
$-514.0K
Q1 24
$-99.9M
$1.1M
Free Cash Flow
AGIO
AGIO
TLF
TLF
Q4 25
$-97.3M
$4.0M
Q3 25
$-89.7M
$-3.0M
Q2 25
$-78.0M
$-7.3M
Q1 25
$-112.3M
$-1.9M
Q4 24
$-134.1M
$3.8M
Q3 24
$-84.6M
$-1.4M
Q2 24
$-72.7M
$-715.0K
Q1 24
$-100.0M
$-141.0K
FCF Margin
AGIO
AGIO
TLF
TLF
Q4 25
-487.5%
18.1%
Q3 25
-696.5%
-17.2%
Q2 25
-626.2%
-41.0%
Q1 25
-1286.4%
-9.8%
Q4 24
-1250.1%
18.8%
Q3 24
-944.2%
-8.2%
Q2 24
-844.4%
-4.1%
Q1 24
-1221.2%
-0.7%
Capex Intensity
AGIO
AGIO
TLF
TLF
Q4 25
5.6%
4.3%
Q3 25
12.1%
11.2%
Q2 25
7.0%
18.7%
Q1 25
8.8%
7.0%
Q4 24
9.0%
3.3%
Q3 24
4.7%
5.1%
Q2 24
1.8%
1.2%
Q1 24
1.7%
6.4%
Cash Conversion
AGIO
AGIO
TLF
TLF
Q4 25
Q3 25
Q2 25
Q1 25
-0.05×
Q4 24
13.55×
Q3 24
-0.09×
Q2 24
-5.09×
Q1 24
2.07×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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