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Side-by-side financial comparison of Amphastar Pharmaceuticals, Inc. (AMPH) and Axsome Therapeutics, Inc. (AXSM). Click either name above to swap in a different company.
Axsome Therapeutics, Inc. is the larger business by last-quarter revenue ($196.0M vs $183.1M, roughly 1.1× Amphastar Pharmaceuticals, Inc.). Amphastar Pharmaceuticals, Inc. runs the higher net margin — 13.3% vs -14.6%, a 27.9% gap on every dollar of revenue. On growth, Axsome Therapeutics, Inc. posted the faster year-over-year revenue change (65.0% vs -1.8%). Amphastar Pharmaceuticals, Inc. produced more free cash flow last quarter ($24.6M vs $-18.7M). Over the past eight quarters, Axsome Therapeutics, Inc.'s revenue compounded faster (61.7% CAGR vs 3.2%).
Amphastar Pharmaceuticals is a publicly traded American speciality pharmaceutical company. It was incorporated in May 2004 and primarily develops, manufactures, and sells inhalation and intranasal products.
Jazz Pharmaceuticals plc is a global biopharmaceutical company with a focus on oncology and neuroscience. It was founded in 2003 in California, United States and is now headquartered in Dublin, Ireland.
AMPH vs AXSM — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $183.1M | $196.0M |
| Net Profit | $24.4M | $-28.6M |
| Gross Margin | 46.8% | — |
| Operating Margin | 19.4% | -13.8% |
| Net Margin | 13.3% | -14.6% |
| Revenue YoY | -1.8% | 65.0% |
| Net Profit YoY | -35.7% | 61.9% |
| EPS (diluted) | $0.51 | $-0.55 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $183.1M | $196.0M | ||
| Q3 25 | $191.8M | $171.0M | ||
| Q2 25 | $174.4M | $150.0M | ||
| Q1 25 | $170.5M | $121.5M | ||
| Q4 24 | $186.5M | $118.8M | ||
| Q3 24 | $191.2M | $104.8M | ||
| Q2 24 | $182.4M | $87.2M | ||
| Q1 24 | $171.8M | $75.0M |
| Q4 25 | $24.4M | $-28.6M | ||
| Q3 25 | $17.4M | $-47.2M | ||
| Q2 25 | $31.0M | $-48.0M | ||
| Q1 25 | $25.3M | $-59.4M | ||
| Q4 24 | $38.0M | $-74.9M | ||
| Q3 24 | $40.4M | $-64.6M | ||
| Q2 24 | $37.9M | $-79.3M | ||
| Q1 24 | $43.2M | $-68.4M |
| Q4 25 | 46.8% | — | ||
| Q3 25 | 51.4% | — | ||
| Q2 25 | 49.6% | — | ||
| Q1 25 | 50.0% | — | ||
| Q4 24 | 46.5% | — | ||
| Q3 24 | 53.3% | — | ||
| Q2 24 | 52.2% | — | ||
| Q1 24 | 52.4% | — |
| Q4 25 | 19.4% | -13.8% | ||
| Q3 25 | 13.2% | -27.0% | ||
| Q2 25 | 24.2% | -24.5% | ||
| Q1 25 | 21.9% | -46.9% | ||
| Q4 24 | 24.2% | -61.1% | ||
| Q3 24 | 29.8% | -59.8% | ||
| Q2 24 | 30.3% | -89.5% | ||
| Q1 24 | 27.9% | -89.7% |
| Q4 25 | 13.3% | -14.6% | ||
| Q3 25 | 9.0% | -27.6% | ||
| Q2 25 | 17.8% | -32.0% | ||
| Q1 25 | 14.8% | -48.9% | ||
| Q4 24 | 20.4% | -63.1% | ||
| Q3 24 | 21.1% | -61.7% | ||
| Q2 24 | 20.8% | -91.0% | ||
| Q1 24 | 25.1% | -91.1% |
| Q4 25 | $0.51 | $-0.55 | ||
| Q3 25 | $0.37 | $-0.94 | ||
| Q2 25 | $0.64 | $-0.97 | ||
| Q1 25 | $0.51 | $-1.22 | ||
| Q4 24 | $0.74 | $-1.54 | ||
| Q3 24 | $0.78 | $-1.34 | ||
| Q2 24 | $0.73 | $-1.67 | ||
| Q1 24 | $0.81 | $-1.44 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $282.8M | $322.9M |
| Total DebtLower is stronger | $608.7M | — |
| Stockholders' EquityBook value | $788.8M | $88.3M |
| Total Assets | $1.6B | $689.8M |
| Debt / EquityLower = less leverage | 0.77× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $282.8M | $322.9M | ||
| Q3 25 | $276.2M | $325.3M | ||
| Q2 25 | $231.8M | $303.0M | ||
| Q1 25 | $236.9M | $300.9M | ||
| Q4 24 | $221.6M | $315.4M | ||
| Q3 24 | $250.5M | $327.3M | ||
| Q2 24 | $217.8M | $315.7M | ||
| Q1 24 | $289.6M | $331.4M |
| Q4 25 | $608.7M | — | ||
| Q3 25 | $608.6M | — | ||
| Q2 25 | $607.7M | — | ||
| Q1 25 | $603.9M | — | ||
| Q4 24 | $601.6M | — | ||
| Q3 24 | $596.4M | — | ||
| Q2 24 | $586.9M | — | ||
| Q1 24 | $594.0M | — |
| Q4 25 | $788.8M | $88.3M | ||
| Q3 25 | $776.7M | $73.7M | ||
| Q2 25 | $757.5M | $73.1M | ||
| Q1 25 | $751.3M | $53.2M | ||
| Q4 24 | $732.3M | $57.0M | ||
| Q3 24 | $727.7M | $92.9M | ||
| Q2 24 | $713.3M | $102.9M | ||
| Q1 24 | $672.4M | $144.0M |
| Q4 25 | $1.6B | $689.8M | ||
| Q3 25 | $1.7B | $669.3M | ||
| Q2 25 | $1.6B | $639.8M | ||
| Q1 25 | $1.6B | $596.7M | ||
| Q4 24 | $1.6B | $568.5M | ||
| Q3 24 | $1.5B | $561.5M | ||
| Q2 24 | $1.5B | $548.2M | ||
| Q1 24 | $1.6B | $545.7M |
| Q4 25 | 0.77× | — | ||
| Q3 25 | 0.78× | — | ||
| Q2 25 | 0.80× | — | ||
| Q1 25 | 0.80× | — | ||
| Q4 24 | 0.82× | — | ||
| Q3 24 | 0.82× | — | ||
| Q2 24 | 0.82× | — | ||
| Q1 24 | 0.88× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $32.9M | $-18.7M |
| Free Cash FlowOCF − Capex | $24.6M | $-18.7M |
| FCF MarginFCF / Revenue | 13.4% | -9.6% |
| Capex IntensityCapex / Revenue | 4.5% | 0.0% |
| Cash ConversionOCF / Net Profit | 1.35× | — |
| TTM Free Cash FlowTrailing 4 quarters | $121.2M | $-93.9M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $32.9M | $-18.7M | ||
| Q3 25 | $52.6M | $1.0M | ||
| Q2 25 | $35.6M | $-32.4M | ||
| Q1 25 | $35.1M | $-43.4M | ||
| Q4 24 | $29.0M | $-26.2M | ||
| Q3 24 | $60.0M | $-18.6M | ||
| Q2 24 | $69.1M | $-30.1M | ||
| Q1 24 | $55.3M | $-53.5M |
| Q4 25 | $24.6M | $-18.7M | ||
| Q3 25 | $47.2M | $988.0K | ||
| Q2 25 | $25.0M | $-32.4M | ||
| Q1 25 | $24.4M | $-43.7M | ||
| Q4 24 | $16.6M | $-26.2M | ||
| Q3 24 | $46.2M | $-18.7M | ||
| Q2 24 | $63.1M | $-30.2M | ||
| Q1 24 | $46.5M | $-53.6M |
| Q4 25 | 13.4% | -9.6% | ||
| Q3 25 | 24.6% | 0.6% | ||
| Q2 25 | 14.3% | -21.6% | ||
| Q1 25 | 14.3% | -36.0% | ||
| Q4 24 | 8.9% | -22.1% | ||
| Q3 24 | 24.1% | -17.9% | ||
| Q2 24 | 34.6% | -34.6% | ||
| Q1 24 | 27.1% | -71.4% |
| Q4 25 | 4.5% | 0.0% | ||
| Q3 25 | 2.8% | 0.0% | ||
| Q2 25 | 6.1% | 0.0% | ||
| Q1 25 | 6.3% | 0.3% | ||
| Q4 24 | 6.7% | 0.0% | ||
| Q3 24 | 7.2% | 0.1% | ||
| Q2 24 | 3.3% | 0.1% | ||
| Q1 24 | 5.1% | 0.1% |
| Q4 25 | 1.35× | — | ||
| Q3 25 | 3.03× | — | ||
| Q2 25 | 1.15× | — | ||
| Q1 25 | 1.39× | — | ||
| Q4 24 | 0.76× | — | ||
| Q3 24 | 1.48× | — | ||
| Q2 24 | 1.82× | — | ||
| Q1 24 | 1.28× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AMPH
| Other Products | $62.4M | 34% |
| Baqsimi | $46.7M | 26% |
| Primatenemist | $27.9M | 15% |
| Epinephrine | $17.1M | 9% |
| Lidocaine | $14.9M | 8% |
| Glucagon | $14.1M | 8% |
AXSM
Segment breakdown not available.
