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Side-by-side financial comparison of Axsome Therapeutics, Inc. (AXSM) and Oportun Financial Corp (OPRT). Click either name above to swap in a different company.

Oportun Financial Corp is the larger business by last-quarter revenue ($247.7M vs $196.0M, roughly 1.3× Axsome Therapeutics, Inc.). Oportun Financial Corp runs the higher net margin — 1.4% vs -14.6%, a 15.9% gap on every dollar of revenue. On growth, Axsome Therapeutics, Inc. posted the faster year-over-year revenue change (65.0% vs -1.3%). Over the past eight quarters, Axsome Therapeutics, Inc.'s revenue compounded faster (61.7% CAGR vs -0.5%).

Jazz Pharmaceuticals plc is a global biopharmaceutical company with a focus on oncology and neuroscience. It was founded in 2003 in California, United States and is now headquartered in Dublin, Ireland.

Oportun Financial Corp is a US-based fintech firm that provides accessible, responsible financial services including personal loans, credit cards, and savings products to underserved low-to-moderate income consumers, many with limited or no credit history, leveraging proprietary AI underwriting to deliver fair terms while mitigating operational risk.

AXSM vs OPRT — Head-to-Head

Bigger by revenue
OPRT
OPRT
1.3× larger
OPRT
$247.7M
$196.0M
AXSM
Growing faster (revenue YoY)
AXSM
AXSM
+66.3% gap
AXSM
65.0%
-1.3%
OPRT
Higher net margin
OPRT
OPRT
15.9% more per $
OPRT
1.4%
-14.6%
AXSM
Faster 2-yr revenue CAGR
AXSM
AXSM
Annualised
AXSM
61.7%
-0.5%
OPRT

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
AXSM
AXSM
OPRT
OPRT
Revenue
$196.0M
$247.7M
Net Profit
$-28.6M
$3.4M
Gross Margin
Operating Margin
-13.8%
2.6%
Net Margin
-14.6%
1.4%
Revenue YoY
65.0%
-1.3%
Net Profit YoY
61.9%
-61.0%
EPS (diluted)
$-0.55
$0.07

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
AXSM
AXSM
OPRT
OPRT
Q4 25
$196.0M
$247.7M
Q3 25
$171.0M
$238.7M
Q2 25
$150.0M
$234.3M
Q1 25
$121.5M
$235.9M
Q4 24
$118.8M
$250.9M
Q3 24
$104.8M
$250.0M
Q2 24
$87.2M
$250.4M
Q1 24
$75.0M
$250.5M
Net Profit
AXSM
AXSM
OPRT
OPRT
Q4 25
$-28.6M
$3.4M
Q3 25
$-47.2M
$5.2M
Q2 25
$-48.0M
$6.9M
Q1 25
$-59.4M
$9.8M
Q4 24
$-74.9M
$8.7M
Q3 24
$-64.6M
$-30.0M
Q2 24
$-79.3M
$-31.0M
Q1 24
$-68.4M
$-26.4M
Operating Margin
AXSM
AXSM
OPRT
OPRT
Q4 25
-13.8%
2.6%
Q3 25
-27.0%
6.0%
Q2 25
-24.5%
4.3%
Q1 25
-46.9%
5.6%
Q4 24
-61.1%
89.6%
Q3 24
-59.8%
-15.8%
Q2 24
-89.5%
-19.6%
Q1 24
-89.7%
-12.2%
Net Margin
AXSM
AXSM
OPRT
OPRT
Q4 25
-14.6%
1.4%
Q3 25
-27.6%
2.2%
Q2 25
-32.0%
2.9%
Q1 25
-48.9%
4.1%
Q4 24
-63.1%
200.1%
Q3 24
-61.7%
-12.0%
Q2 24
-91.0%
-12.4%
Q1 24
-91.1%
-10.6%
EPS (diluted)
AXSM
AXSM
OPRT
OPRT
Q4 25
$-0.55
$0.07
Q3 25
$-0.94
$0.11
Q2 25
$-0.97
$0.14
Q1 25
$-1.22
$0.21
Q4 24
$-1.54
$0.26
Q3 24
$-1.34
$-0.75
Q2 24
$-1.67
$-0.78
Q1 24
$-1.44
$-0.68

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
AXSM
AXSM
OPRT
OPRT
Cash + ST InvestmentsLiquidity on hand
$322.9M
$105.5M
Total DebtLower is stronger
Stockholders' EquityBook value
$88.3M
$390.1M
Total Assets
$689.8M
$3.3B
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
AXSM
AXSM
OPRT
OPRT
Q4 25
$322.9M
$105.5M
Q3 25
$325.3M
$104.6M
Q2 25
$303.0M
$96.8M
Q1 25
$300.9M
$78.5M
Q4 24
$315.4M
$60.0M
Q3 24
$327.3M
$71.8M
Q2 24
$315.7M
$72.9M
Q1 24
$331.4M
$69.2M
Stockholders' Equity
AXSM
AXSM
OPRT
OPRT
Q4 25
$88.3M
$390.1M
Q3 25
$73.7M
$383.9M
Q2 25
$73.1M
$376.0M
Q1 25
$53.2M
$366.1M
Q4 24
$57.0M
$353.8M
Q3 24
$92.9M
$327.6M
Q2 24
$102.9M
$354.1M
Q1 24
$144.0M
$382.0M
Total Assets
AXSM
AXSM
OPRT
OPRT
Q4 25
$689.8M
$3.3B
Q3 25
$669.3M
$3.2B
Q2 25
$639.8M
$3.2B
Q1 25
$596.7M
$3.2B
Q4 24
$568.5M
$3.2B
Q3 24
$561.5M
$3.3B
Q2 24
$548.2M
$3.3B
Q1 24
$545.7M
$3.3B

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
AXSM
AXSM
OPRT
OPRT
Operating Cash FlowLast quarter
$-18.7M
$413.4M
Free Cash FlowOCF − Capex
$-18.7M
FCF MarginFCF / Revenue
-9.6%
Capex IntensityCapex / Revenue
0.0%
Cash ConversionOCF / Net Profit
121.45×
TTM Free Cash FlowTrailing 4 quarters
$-93.9M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
AXSM
AXSM
OPRT
OPRT
Q4 25
$-18.7M
$413.4M
Q3 25
$1.0M
$99.0M
Q2 25
$-32.4M
$104.5M
Q1 25
$-43.4M
$101.0M
Q4 24
$-26.2M
$393.5M
Q3 24
$-18.6M
$108.5M
Q2 24
$-30.1M
$107.7M
Q1 24
$-53.5M
$85.9M
Free Cash Flow
AXSM
AXSM
OPRT
OPRT
Q4 25
$-18.7M
Q3 25
$988.0K
Q2 25
$-32.4M
Q1 25
$-43.7M
Q4 24
$-26.2M
Q3 24
$-18.7M
Q2 24
$-30.2M
Q1 24
$-53.6M
FCF Margin
AXSM
AXSM
OPRT
OPRT
Q4 25
-9.6%
Q3 25
0.6%
Q2 25
-21.6%
Q1 25
-36.0%
Q4 24
-22.1%
Q3 24
-17.9%
Q2 24
-34.6%
Q1 24
-71.4%
Capex Intensity
AXSM
AXSM
OPRT
OPRT
Q4 25
0.0%
Q3 25
0.0%
Q2 25
0.0%
Q1 25
0.3%
Q4 24
0.0%
Q3 24
0.1%
Q2 24
0.1%
Q1 24
0.1%
Cash Conversion
AXSM
AXSM
OPRT
OPRT
Q4 25
121.45×
Q3 25
19.05×
Q2 25
15.20×
Q1 25
10.34×
Q4 24
45.04×
Q3 24
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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