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Side-by-side financial comparison of Guardant Health, Inc. (GH) and Oportun Financial Corp (OPRT). Click either name above to swap in a different company.
Guardant Health, Inc. is the larger business by last-quarter revenue ($281.3M vs $247.7M, roughly 1.1× Oportun Financial Corp). Oportun Financial Corp runs the higher net margin — 1.4% vs -45.7%, a 47.1% gap on every dollar of revenue. On growth, Guardant Health, Inc. posted the faster year-over-year revenue change (39.4% vs -1.3%). Over the past eight quarters, Guardant Health, Inc.'s revenue compounded faster (29.2% CAGR vs -0.5%).
Guardant Health, Inc. is an American biotechnology company based in Palo Alto, California. Co-founders Helmy Eltoukhy and AmirAli Talasaz serve as co-chief executive officers.
Oportun Financial Corp is a US-based fintech firm that provides accessible, responsible financial services including personal loans, credit cards, and savings products to underserved low-to-moderate income consumers, many with limited or no credit history, leveraging proprietary AI underwriting to deliver fair terms while mitigating operational risk.
GH vs OPRT — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $281.3M | $247.7M |
| Net Profit | $-128.5M | $3.4M |
| Gross Margin | 64.6% | — |
| Operating Margin | -43.0% | 2.6% |
| Net Margin | -45.7% | 1.4% |
| Revenue YoY | 39.4% | -1.3% |
| Net Profit YoY | -15.8% | -61.0% |
| EPS (diluted) | $-1.01 | $0.07 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $281.3M | $247.7M | ||
| Q3 25 | $265.2M | $238.7M | ||
| Q2 25 | $232.1M | $234.3M | ||
| Q1 25 | $203.5M | $235.9M | ||
| Q4 24 | $201.8M | $250.9M | ||
| Q3 24 | $191.5M | $250.0M | ||
| Q2 24 | $177.2M | $250.4M | ||
| Q1 24 | $168.5M | $250.5M |
| Q4 25 | $-128.5M | $3.4M | ||
| Q3 25 | $-92.7M | $5.2M | ||
| Q2 25 | $-99.9M | $6.9M | ||
| Q1 25 | $-95.2M | $9.8M | ||
| Q4 24 | $-111.0M | $8.7M | ||
| Q3 24 | $-107.8M | $-30.0M | ||
| Q2 24 | $-102.6M | $-31.0M | ||
| Q1 24 | $-115.0M | $-26.4M |
| Q4 25 | 64.6% | — | ||
| Q3 25 | 64.7% | — | ||
| Q2 25 | 65.0% | — | ||
| Q1 25 | 63.3% | — | ||
| Q4 24 | 61.6% | — | ||
| Q3 24 | 61.1% | — | ||
| Q2 24 | 59.1% | — | ||
| Q1 24 | 61.2% | — |
| Q4 25 | -43.0% | 2.6% | ||
| Q3 25 | -37.3% | 6.0% | ||
| Q2 25 | -45.9% | 4.3% | ||
| Q1 25 | -54.6% | 5.6% | ||
| Q4 24 | -62.4% | 89.6% | ||
| Q3 24 | -61.3% | -15.8% | ||
| Q2 24 | -56.8% | -19.6% | ||
| Q1 24 | -59.2% | -12.2% |
| Q4 25 | -45.7% | 1.4% | ||
| Q3 25 | -35.0% | 2.2% | ||
| Q2 25 | -43.0% | 2.9% | ||
| Q1 25 | -46.8% | 4.1% | ||
| Q4 24 | -55.0% | 200.1% | ||
| Q3 24 | -56.3% | -12.0% | ||
| Q2 24 | -57.9% | -12.4% | ||
| Q1 24 | -68.2% | -10.6% |
| Q4 25 | $-1.01 | $0.07 | ||
| Q3 25 | $-0.74 | $0.11 | ||
| Q2 25 | $-0.80 | $0.14 | ||
| Q1 25 | $-0.77 | $0.21 | ||
| Q4 24 | $-0.90 | $0.26 | ||
| Q3 24 | $-0.88 | $-0.75 | ||
| Q2 24 | $-0.84 | $-0.78 | ||
| Q1 24 | $-0.94 | $-0.68 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $378.2M | $105.5M |
| Total DebtLower is stronger | $1.5B | — |
| Stockholders' EquityBook value | $-99.3M | $390.1M |
| Total Assets | $2.0B | $3.3B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $378.2M | $105.5M | ||
| Q3 25 | $580.0M | $104.6M | ||
| Q2 25 | $629.1M | $96.8M | ||
| Q1 25 | $698.6M | $78.5M | ||
| Q4 24 | $525.5M | $60.0M | ||
| Q3 24 | $585.0M | $71.8M | ||
| Q2 24 | $933.7M | $72.9M | ||
| Q1 24 | $1.0B | $69.2M |
| Q4 25 | $1.5B | — | ||
| Q3 25 | $1.1B | — | ||
| Q2 25 | $1.1B | — | ||
| Q1 25 | $1.1B | — | ||
| Q4 24 | $1.1B | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $-99.3M | $390.1M | ||
| Q3 25 | $-354.5M | $383.9M | ||
| Q2 25 | $-305.5M | $376.0M | ||
| Q1 25 | $-250.8M | $366.1M | ||
| Q4 24 | $-139.6M | $353.8M | ||
| Q3 24 | $-60.1M | $327.6M | ||
| Q2 24 | $-1.6M | $354.1M | ||
| Q1 24 | $68.3M | $382.0M |
| Q4 25 | $2.0B | $3.3B | ||
| Q3 25 | $1.3B | $3.2B | ||
| Q2 25 | $1.3B | $3.2B | ||
| Q1 25 | $1.3B | $3.2B | ||
| Q4 24 | $1.5B | $3.2B | ||
| Q3 24 | $1.5B | $3.3B | ||
| Q2 24 | $1.6B | $3.3B | ||
| Q1 24 | $1.7B | $3.3B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-26.4M | $413.4M |
| Free Cash FlowOCF − Capex | $-54.2M | — |
| FCF MarginFCF / Revenue | -19.3% | — |
| Capex IntensityCapex / Revenue | 9.9% | — |
| Cash ConversionOCF / Net Profit | — | 121.45× |
| TTM Free Cash FlowTrailing 4 quarters | $-233.1M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-26.4M | $413.4M | ||
| Q3 25 | $-35.4M | $99.0M | ||
| Q2 25 | $-60.3M | $104.5M | ||
| Q1 25 | $-62.7M | $101.0M | ||
| Q4 24 | $-64.5M | $393.5M | ||
| Q3 24 | $-51.1M | $108.5M | ||
| Q2 24 | $-94.0M | $107.7M | ||
| Q1 24 | $-30.3M | $85.9M |
| Q4 25 | $-54.2M | — | ||
| Q3 25 | $-45.8M | — | ||
| Q2 25 | $-65.9M | — | ||
| Q1 25 | $-67.1M | — | ||
| Q4 24 | $-83.4M | — | ||
| Q3 24 | $-55.3M | — | ||
| Q2 24 | $-99.1M | — | ||
| Q1 24 | $-37.2M | — |
| Q4 25 | -19.3% | — | ||
| Q3 25 | -17.3% | — | ||
| Q2 25 | -28.4% | — | ||
| Q1 25 | -33.0% | — | ||
| Q4 24 | -41.3% | — | ||
| Q3 24 | -28.9% | — | ||
| Q2 24 | -55.9% | — | ||
| Q1 24 | -22.1% | — |
| Q4 25 | 9.9% | — | ||
| Q3 25 | 3.9% | — | ||
| Q2 25 | 2.4% | — | ||
| Q1 25 | 2.2% | — | ||
| Q4 24 | 9.4% | — | ||
| Q3 24 | 2.2% | — | ||
| Q2 24 | 2.9% | — | ||
| Q1 24 | 4.1% | — |
| Q4 25 | — | 121.45× | ||
| Q3 25 | — | 19.05× | ||
| Q2 25 | — | 15.20× | ||
| Q1 25 | — | 10.34× | ||
| Q4 24 | — | 45.04× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
GH
| Oncology | $189.9M | 68% |
| Biopharma Data | $54.0M | 19% |
| Screening | $35.1M | 12% |
| Licensing Other | $2.2M | 1% |
OPRT
Segment breakdown not available.
